These organisms belong to a group of carbapenem-resistant, gram-negative bacteria of national and international concern because of their implication as an emerging cause of severe healthcare-associated infections. In , the World Health Organization published the first global guidelines for the prevention and control of CRE-CRAB-CRPsA in healthcare facilities, which include environmental cleaning and disinfection as a key recommendation.

Hospitalized patients&#x; security in intensive care units should be ensured using protective devices, which may be evaluated for human security during UV-C emission at specific dosages and times. Considering the lack of literature data about these possible strategies, the use of a UV-C robot in the presence of persons still represents a critical issue that may be taken into account for the development of safe and effective technologies.

In settings where hospital cleaning services are assigned to private sector contractors, the use of new no-touch technologies could be considered in outsourcing contracts as an improvement action in the event of non-compliance in the cleaning service. The dedicated personnel should be adequately trained not only on the cleaning protocols to be adopted but also on infection control issues, underlining the key role of cleaning procedures.

The disinfection of the air with UV-C is performed by irradiating the upper-room air only, the whole room when unoccupied, or the air flowing inside the air-handling units. The study conducted by McGinn et al. demonstrated the feasibility of using a UV-C robotic system to disinfect both air and surfaces in a radiology environment, where it was two and four times faster than currently used chemical approaches [

Moreover, it would be important to evaluate the advantages of implemented cleaning and disinfection protocols with the use of UV-C devices in areas hosting fragile and vulnerable patients, e.g., in intensive care units. The principal limitation is the continuous presence of people in this type of setting. For this reason, it would be worth evaluating strategies aimed at protecting the patient&#x;s safety using protective devices, which may be evaluated for human security during UV-C emission at specific dosages and times.